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Professor MOHAMMED HAIDAR

Prof. Mohammad Haider
Phone
24636475
Public Email
m.haider@ku.edu.kw
Office Location
College of Medicine, Jabriya, 4th Floor, Department of Obstetrics and Gynecology
College/ Center
College of Medicine
Professor

Prof. Mohammad Haider

Specialization: Medical Genetics

Research Theme: “Investigating the role of genetic factors in common chronic diseases” 

The current research in my Labs uses molecular genetic/genomic approaches to investigate the genotype-phenotype correlation in common chronic diseases (hemoglobin disorders, type-1 diabetes and diseases with autoimmune and inflammatory etiologies). This has yielded significant data which has formed the basis for efficient patient and family counseling in many of the disease entities targeted. Early detection of the genotype in some cases (e.g. hemoglobin disorders) has contributed to designing appropriate patient management strategies which has a direct impact on the patient care. The research carried out at KU is amongst the first such studies conducted in Kuwaiti Arab population and some of the findings constitute first such reports from the region. 

Degrees and Certificates

PhD                     Cambridge University, Cambridge, U.K.

Fellowship        Harvard Medical School, Department of Genetics, Boston, MA, USA 

Certificate in Computer programming (FORTRAN-4).

Key Responsibilities
  1. Chairman, Department of Obstetrics and Gynecology, College of Medicine, Kuwait University
  2. Editor-in-Chief, Medical Principles and Practice, (an international journal with Q1 ranking by Clarivate, 2023)
  3. Director, Graduate Program in Molecular Biology, College of Graduate Studies, Kuwait University
Professional Experience

PROFESSIONAL AFFILIATIONS AND ACADEMIC CONTRIBUTIONS

Membership of Professional Organizations

  1. Fellow: Cambridge Philosophical Society, U.K. (1985).
  2. Member:The Biochemical Society, U.K. (1986-94).
  3. Member: Society for General Microbiology, U.K. (1986-94).            
  4. Member: Professional section - American Diabetes Association (1999-2001).
  5. Member: American Association for the Advancement of Science, AAAS (2003).
  6. Member: American Society for Cell Biology (2013-2015).
  7. Member: European Society of Human Genetics (till 2018).
  8. Member: American Society of Human Genetics (till present).
  9. Member: Kuwait University Faculty Association (till present).

  10. Member: Cambridge University Alumni Network (for life).

     

 

Membership of Journal Editorial Boards

1.Editor-in-Chief: Medical Principles and Practice (June 2024 – present)

2.Associate Editor: BMC Pediatrics (2018-2020).

3. Member, Editorial Board, BMC Pediatrics (From September 2020-present)

  1. Member, Editorial Board, American Journal of Pediatrics
  2. Associate Editor: Frontiers in Genetics (Applied Genetic Epidemiology Section; 2021- present).
  3. Associate Editor: World Allergy Organization Journal (2024-present).
  4. Member, Editorial Board, BMC Medical Genomics (2023 – present).
  5. Section Editor (Genetics): Annals of Clinical and Experimental Immunology.
  6. Member, Editorial Board: Journal of Diabetes Care and Endocrinology.
  7. Section Editor (Genetics): Journal of Pediatrics and Pediatric Medicine.
  8. Member, Editorial Board: SM Pediatrics and Neonatal Biology.

 

Service as Referee for International Journals and Funding Bodies

  1. Reviewer for the evaluation of Kuwait University Research Sector’s funded projects (for several projects).
  2. Reviewer for the journal Molecular Psychiatry (2002).
  3. Reviewer for American Journal of Pharmacogenomics (2003).
  4. Reviewer for Archives of Diseases in Childhood (2003).
  5. Member: International Referee Panel of the Journal Medical Science Monitor (2003).
  6. Reviewer for Medical Principles and Practice (2004, 2005, 2006, 2010; 2016; 2018, 2019, 2021).
  7. Reviewer for BMC Pediatrics (2004, 2008, 2019).
  8. Reviewer for Journal of Infectious Diseases (2006).
  9. Reviewer for BMC Ophthalmology (2006).
  10. Reviewer for the journal Pediatrics (2006).
  11. Reviewer for Kuwait Medical Journal (2006, 2007, 2008, 2009, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2019).
  12. Reviewer for the journal Neuroscience Letters (2007).
  13. Reviewer for Yonsei Medical Journal, Korea (2007).
  14. Reviewer for Annals of Thoracic Medicine (2008).
  15. Reviewer for BMC Genetics (July 2008).
  16. Reviewer for Annals of Saudi Medicine (July 2009; April 2014; May 2014; August 2014; September 2014; December 2014; February 2015).
  17. Reviewer for Pediatric Nephrology (November 2009).
  18. Reviewer for Journal of the Renin-Angiotensin-Aldosterone System (November 2013).
  19. Reviewer for Journal of Genetics (February 2014).
  20. Reviewer for Annals of Hematology & Oncology (August 2016).
  21. Served as Reviewer for Translational Pediatrics (September 2016).
  22. Served as Reviewer for the journal Research in Pediatrics and Neonatology (September 2017).
  23. Served as Reviewer: for the Journal Annals of Clinical Immunology and Microbiology (March 2018).
  24. Served as Reviewer: for research project submitted to Ministry of health, Kuwait for funding by Kuwait Medical Genetics Center (June 2019).
  25. Served as Reviewer: for the journal Archives of Physiology & Biochemistry (October 2019).
  26. Served as Reviewer: for the journal Endocrine connections (April 2020).
  27. Served as Reviewer: for the journal Molecular Biology Reports (July 2020)
  28. Served as Reviewer: for the journal Annals of Translational Medicine (August 2020).
  29. Served as Reviewer: for World Allergy Organization Journal (March 2024).

 

Contribution to GeneBank/EMBL Databases

1. Determined the nucleotide sequence of 4.3 kb entomocidal crystal protein gene from Bt aizawai (Accession No. X13233).

Research Interests

Role of genetic factors in common chronic disorders

Publications

 FULL PAPERS IN REFEREED/ INDEXED JOURNALS 

Times cited, excluding self-citations till Nov. 2024 = 1627* (total 107 publications included in Clarivate/JCR's Author & Citation index)

h-index = 26 (*Source: Web of Science, Clarivate Analytics).

a) Papers published before Ph.D. (1981-1982)

The research during this stage of the career focused on understanding the biochemical/molecular basis and endocrine regulation of sperm motility in animal models with an aim to develop strategies for male contraception.

  1. Arslan M, Haider MZ and Qazi MH (1982) Androgen dependent proteins of the primate epididymis. International Journal of Primatology 3(3):257.

  2. Haider MZ, Qazi MH, Khanum A and Arslan M (1983) Effect of testosterone on epididymal proteins in castrated rhesus monkey. American Journal of Primatology 4(1):73-90.

  3. Qadri MI, Haider MZ, Ahmad W, Naqvi SMS and Khanum A (1985) Identification of cAMP binding proteins in the Leydig cell and seminiferous tubules of mouse. Pak Journal of Zoology 19(1):339-348.

  4. Arslan M, Haider MZ and Qazi MH (1986) Characterization and androgen dependence of specific proteins in epididymis of adult rhesus monkey. Archives of Andrology 16:67-74.

  5. Ahmad W, Naqvi SMS, Haider MZ and Khanum A. (1987) Studies on soluble proteins in the epididymis of goat (Capra hircus). Pak Journal of Zoology 19(3):231-237.

  6. Qadri MI, Haider MZ, Ahmad W and Khanum A (1987) Mechanism of transfer of cAMP from cytoplasm to the nucleus. Pak Journal of Zoology 19(1):63-68.

  7. Naqvi SMS, Ahmad W, Haider MZ and Khanum A (1988) Effect of androgen on the epididymal enzymes of goat (Capra hircus). Pak Journal of Biochemistry 21:61-67.

  8. Ahmad W, Naqvi SMS, Haider MZ and Khanum A (1990) Effect of androgen on epididymal proteins in the goat (Capra hircus). Pak Journal of Scientific and Industrial Research 33(12):542-545.

     

b) Papers from Ph.D. Thesis (1984-1987)

The aim of the project was to understand the biochemical and molecular basis of specificity in bacterial toxins. The project also identified the gene encoding a dual-action bacterial toxin using DNA probes and by studying the expression of cloned genomic fragments using an in vitro transcription-translation system.

  1. Haider MZ, Knowles BH and Ellar DJ (1986) Specificity of Bacillus thuringiensis var.colmeri insecticidal delta-endotoxin is determined by differential proteolytic processing of the protoxin by larval gut proteases. European Journal of Biochemistry 156:531-540.

  2. Haider MZ, Ward ES and Ellar DJ (1987) Cloning and heterologous expression of an insecticidal delta-endotoxin from Bacillus thuringiensis var. aizawai IC1 toxic to both lepidoptera and diptera. Gene 52:285-290.

  3. Haider MZ and Ellar DJ (1987) Characterization of the toxicity and cytopathic specificity of a cloned Bacillus thuringiensis crystal protein using insect cell culture. Molecular Microbiology 1(1):59-66.

  4. Haider MZ and Ellar DJ (1987) Analysis of the molecular basis of insecticidal specificity of Bacillus thuringiensis delta-endotoxins. Biochemical Journal 248(1):197-201.

 

Post-PhD publications:

c) Papers from post-doctoral research at Cambridge University (1987-1988)

During this period, site directed mutagenesis was employed to introduce specific alterations in the cloned toxin gene to identify the molecular sites responsible for imparting toxin specificity and activity. Also, the complete nucleotide sequence of one of the dual specificity bacterial toxin gene was determined by Sanger’s DNA sequencing method.

  1. Haider MZ and Ellar DJ (1988) Nucleotide sequence of a Bacillus    thuringiensis aizawai IC1 entomocidal crystal protein gene. Nucleic Acids Research 16 (22):10927

  2. Haider MZ and Ellar DJ (1989) Functional mapping of an entomocidal delta-endotoxin: single amino acid changes produced by site directed mutagenesis influence toxicity and specificity of the protein. Journal of Molecular Biology 208:183-194

  3. Haider MZ, Smith GP and Ellar DJ (1989) Delineation of toxin coding fragments and an insect specificity region of a dual toxicity Bacillus thuringiensis crystal protein gene. FEMS Microbiology Letters 58:157-164

  4. Haider MZ and Ellar DJ (1989) Mechanism of action of Bacillus thuringiensis delta endotoxin: interaction with phospholipid vesicles. Biochimica Biophysica Acta 978:216-222.

     

d) Papers resulting from projects with Kuwait Institute for Scientific Research (KISR; 1989-1990)

The research during this period carried further the work initiated at Cambridge, UK on the mechanism of action of bacterial protein toxins. Secondly, the genetics of methanol utilizing bacteria was studied with the aim of using them as a substrate for production of single cell protein biomass for potential usage in animal feeds.

  1. Haider MZ and Mahmood S (1990) Bacillus thuringiensis insecticidal endotoxin: diversity of crystal proteins and its relatedness to the toxicity spectrum. Journal of Basic Microbiology 30(4):251-258

  2. Haider MZ and Mahmood S (1990) Interaction of the mosquitocidal crystal proteins from Bacillus thuringiensis israelensis with phospholipid vesicles. Pak Journal of Biochemistry 23(1&2):193-198

  3. Haider MZ, Al-Taho N, Al-Salameen F, Kadri MH, Al-Amad S and Spanier E (1991) Efficient transformation of thermotolerant methanol utilizing strains of Methylophilus spp. via electroporation. Acta Biotechnologica 4:295-301

  4. Al-Taho N, Al-Amad S, Al-Salameen F, Spanier E and Haider MZ (1991) Host-vector system for a thermotolerant methanol utilizing bacterium Methylophilus spp. KISRI. Current Microbiology 22:199-202.

     

e) Papers from Quaid-i-Azam University Islamabad, Pakistan (1991-92)

In this period, research was undertaken to evaluate the endocrine status and study the regulatory mechanisms involved in breast cancer patients undergoing adjuvant chemotherapy.

  1. Baig SM, Khan S, Anjum S, Khanum A, Haider MZ and Qazi MH, Zaidi P and Kizilbash NA (1991) Carcinoembryonic antigen (CEA) and beta subunit of human chorionic gonadotrophin as markers of human breast cancer. Pak Journal of Zoology 24:71-76

  2. Anjum S, Baig SM, Khan S, Khanum A, Haider MZ and Qazi MH (1991) Effect of chemotherapy on circulating steroid hormone levels in postoperative premenopausal breast cancer patients. Journal of Pak Medical Association 41:296-298

  3. Khan S, Anjum S, Baig SM, Khanum A, Haider MZ and Qazi MH (1991) Effect of anticancer chemotherapy on the circulating levels of FSH, LH and PRL in post-operative premenopausal breast cancer patients. Pak Journal of Zoology 23(4):301-303

  4. Khan S, Anjum S, Baig SM, Khanum A, Haider MZ and Qazi MH (1991) Studies on the in vitro and in vivo release of hormonal steroids bound to a polymer base. Pak Journal of Zoology 23(3):263-268

  5. Baig SM, Anjum S, Khan S, Khanum A, Qazi MH and Haider MZ (1991) Circulating levels of E2, testosterone and progesterone in postmenopausl breast cancer patients receiving anticancer chemotherapy. Pak Journal of Zoology 23(4):335-338

  6. Mahmood S and Haider MZ (1994) Activation of adenyl cyclase in insect midgut membrane vesicles by Bacillus thuringiensis delta endotoxins and melittin. Pak Journal of Biochemistry 27:63-68

  7. Haider M. (1995) Effect of adjuvant chemotherapy on the circulating levels of pituitary hormones in postmenopausal breast cancer patients. Annals of Saudi Medicine 15 (5):470-472.

 

f) Full Papers published from Kuwait University in refereed/indexed journals (1993-present)

Research Theme:   “Role of genetic factors in common chronic diseases” 

The current research uses molecular genetic approach to investigate the genotype-phenotype correlation in common chronic diseases (hemoglobin disorders, type-1 diabetes and diseases with autoimmune and inflammatory etiologies). This has yielded significant data which has formed the basis for efficient patient and family counseling in many of the disease entities targeted. Early detection of the genotype in some cases (e.g. hemoglobin disorders) has contributed to designing appropriate patient management strategies which has a direct impact on the patient care. The research carried out at KU is amongst the first such studies conducted in Kuwaiti Arab population and some of the findings constitute first such reports from the region. 

  1.  Adekile AD, Gu L-H, Baysal E., Haider MZ, Al-Fuzae L, Aboobacker KC, Al-Rashied A and Huisman THJ (1994) Molecular characterization of a- Thalassemia determinants, b Thalassemia alleles and bs haplotypes among Kuwaiti Arabs. Acta Haematologica 92:176-181.

  2. Adekile AD, Tuli M, Haider MZ, Al-Zaabi K, Mohamadi S and Owunwanne A (1996) Influence of Alpha-Thalassemia trait on spleen function in Sickle Cell Anemia patients with high HbF. American Journal of Hematology 53:1-5.

  3. Adekile AD and Haider MZ (1996) Morbidity, bs Haplotype and alpha globin gene patterns among Sickle cell anemia patients in Kuwait. Acta Haematologica 96:150-154.

  4. Adekile AD and Haider MZ (1996) Genetic epidemiology of sickle cell anemia and a-/b-Thalassemia in Kuwait. Kuwait Medical Journal 28 (2):104-110 [Review].

  5. Haider MZ and Moosa A (1997) Gene deletions in Arab patients with spinal muscular atrophy. Journal of Child Neurology 12(5):310-313.

  6. Haider MZ, Bastaki L, Habib Y and Moosa A (1998) Screening 25 Dystrophin gene exons for deletions in Arab children with Duchenne muscular dystrophy. Human Heredity 48:61-66.

  7. Haider MZ and Hijazi Z (1998) Prevalence of high affinity IgE receptor (FceRIb) gene polymorphisms in Kuwaiti Arabs with asthma.Clinical Genetics 54:166-167.

  8. Hijazi Z, Haider MZ, Khan MR, Al-Dowaisan AA (1998) High frequency of IgE receptor [FceRIb] variant (Leu181/Leu183) in Kuwaiti Arabs and its association with asthma. Clinical Genetics 53:149-152.

  9. Haider MZ, Ashebu S, Adu P, Adekile AD, (1998) Influence of alpha Thalassemia on Cholelithiasis in SS patients with elevated HbF. Acta Haematologica 100:147-150.

  10. Adekile AD, Haider MZ, Serebour F, Zaabi K and Tuli M (1999) Serum Immunoglobulins in SS patients with Saudi Arabia/India Haplotype. Medical Principles and Practice 8(3):183-188.

  11. Haider MZ, Raghupathy R, Azizieh F, Abdelsalam R, D’Souza TM, Adekile AD (1999) GM-CSF in Sickle Cell Anemia patients with elevated HbF. Acta Haematologica 102(3):140-143.

  12. Haider MZ and Hijazi Z (1999) Prevalence of Angiotensin converting enzyme gene polymorphism in Kuwaiti Arabs with asthma. Medical Science Research 27:553-556. 

  13. Haider MZ, Shaltout A, Alsaeid, K, Qabazard M, Dorman J. (1999) Prevalence of HLA-DQA1 and DQB1 alleles in Kuwaiti Arab children with type-1 diabetes mellitus. Clinical Genetics 56(6):450-456.

  14. Bastaki L, Haider MZ, Shawky RM, Naguib KK (1999) Genotype-phenotype correlation among patients with dystrophinopathies. Alexandria Journal of Pediatrics 13(2):365-371.

  15. Haider MZ, Shaltout A, Alsaeid K, Al-Khawari M, Dorman JS. (2000) High frequency of HLA-DQB1 non- Asp57 alleles in Kuwaiti children with insulin dependent diabetes mellitus. Human Heredity 50(4):242-246.

  16. Haider MZ, Devarajan LV, Al-Essa M, Srivastva BS, Kumar H, Azad R, Rashwan N (2000) Missense mutations in Norrie disease gene are not associated with advanced stages of Retinopathy of prematurity in Kuwaiti Arabs. Biology of the Neonate 77(2):88-91.

  17. Hijazi Z, Haider MZ (2000) Interleukin-4 gene promoter polymorphism [C590T] and asthma in Kuwaiti Arabs. International Archives of Allergy & Immunology 122(3):190-194.

  18. Raghupathy R, Haider MZ, Azizieh F, D’Souza TM, Abdelsalam R, Adekile AD. (2000) Tumor Necrosis Factor-a is undetectable in the plasma of SS patients with elevated HbF. American Journal of Hematology 64(2):91-94.

  19. Raghupathy R, Haider MZ, Azizieh F, Abdelsalam R, D’Souza TM, Adekile AD. (2000) Th1 and Th2 Cytokine profiles in Sickle Cell Disease. Acta Haematologica 103(4)197-202.

  20. Diejomaoh FME, Haider MZ, Dalal H, Abdulaziz A, D'Souza TM, Adekile AD. (2000) Influence of a-Thalassemia trait on the prevalence and severity of anemia in pregnancy among women in Kuwait. Acta Haematologica 104(2-3):92-94.

  21. Al-Eisa A, Haider MZ, Srivastva BS (2000) Angiotensin converting enzyme gene insertion/deletion polymorphism and renal damage in childhood uropathies. Pediatrics International 42 (4):348-353.

  22. Al-Eisa A, Haider MZ, Srivastva BS. (2000) HLA-DR alleles in Kuwaiti children with idiopathic nephrotic syndrome. Pediatric Nephrology 15(1-2):79-81.

  23. Haider MZ, Zahid MA, Dalal H.N, Razik MA (2000) Human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti Arabs with schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics) 96(6):870-872.

  24. Al-Eisa A, Haider MZ, Srivastva BS. (2001) Angiotensin converting enzyme gene insertion/deletion polymorphism in idiopathic nephrotic syndrome. Scandinavian Journal of Urology and Nephrology 35:239-242.

  25. Haider MZ, Moosa A, Dalal H, Habib Y, Reynold L (2001) Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes. Journal of Biomedical Science 8(2):191-196.

  26. Hijazi Z, Haider MZ. (2001) Influence of consanguinity and IgE receptor genotypes on clinical manifestations of asthma in Kuwaiti children. Journal of Tropical Pediatrics 47(1):13-16.

  27. Adekile AD, Gupta R, Yacoub F, Sinan T, Al-Bloushi M, Haider MZ. (2001) Avascular necrosis of the hip in children with Sickle cell disease and high HbF: Magnetic Resonance Imaging findings and influence of alpha Thalassemia Trait. Acta Haematologica 105(1):27-31.

  28. Adekile AD, Kutlar F, Haider MZ, Kutlar A. (2001) Frequency of the 677CàT mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients. American Journal of Hematology 66(4):263-266.

  29. Haider MZ, Devarajan LV, Al-Essa M, Srivastva BS, Kumar H, Azad R, Rashwan N (2001) Retinopathy of prematurity: mutations in the Norrie disease gene and the risk of progression to advanced stages. Pediatrics International 43(2):120-123.

  30. Haider, MZ, Devarajan LV, Al-Essa M, Kumar H. (2002) Angiotensin converting enzyme gene insertion/deletion polymorphism in Kuwaiti children with retinopathy of prematurity. Biology of the Neonate 82(2):84-88.

  31. Haider, MZ, Devarajan LV, Al-Essa M, Kumar H. (2002) C597 àA polymorphism in Norrie disease gene is associated with advanced retinopathy of prematurity. Journal of Biomedical Science 9(4):365-370.

  32. Haider MZ, Zahid MA. (2002) No evidence for an association between the 5-hydroxytryptmine 5HT2a receptor gene and schizophrenia in Kuwaiti Arabs. Psychiatry and Clinical Neurosciences 56(4):465-467.

  33. Alsaeid K, Haider MZ, Kamal H, Srivastva BS, Ayoub EM. (2002) Prevalence of Human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with Juvenile rheumatoid arthritis. European Journal of Immunogenetics 29(1):1-5.

  34. Adekile AD, Owunwanne A, Al-Za’abi K, Haider MZ, Tuli M, Al-Mohannadi S. (2002) Temporal sequence of splenic dysfunction in sickle cell disease. American Journal of Hematology 69(1):23-27.

  35. Adekile AD, Yacoub F, Gupta R, Sinan T, Haider MZ, Habib Y, Al-Bloushi M, Moosa A. (2002) Silent brain infarcts are rare in sickle cell patients with high HbF. American Journal of Hematology 70(3):228-231.

  36. Alsaeid K, Haider MZ, Al-Awadi AM, Srivastva BS, Ayoub EM. (2003) Role of Human Leukocyte Antigen DRB1*0307 and *0308 in susceptibility to juvenile rheumatoid arthritis. Clinical and Experimental Rheumatology 21(3):399-402.

  37. Alsaeid K, Haider MZ, Ayoub EM. (2003) Angiotensin converting enzyme gene insertion-deletion polymorphism is associated with juvenile rheumatoid arthritis. Journal of Rheumatology 30(12):2705-2709.

  38. Marouf R, Gupta R, Haider MZ, Al-Wazzan H, Adekile AD. (2003) Avascular necrosis of the femoral head in adult Kuwaiti sickle cell disease patients. Acta Haematologica 110(1):11-15.

  39. Marouf R, Gupta R, Haider MZ, Adekile AD. (2003) Silent brain infarcts in adult Kuwaiti sickle cell disease patients. American Journal of Hematology 73(4):240-243.

  40. Haider MZ, Zahid MA. (2004) Human leukocyte antigen (HLA) DQB1 alleles are not associated with schizophrenia in Kuwaiti Arabs. Psychiatry and Clinical Neurosciences 58(3):236-239.

  41. Alsaeid M, Moussa MAA, Haider MZ, Refai TM, Abdella N, Al-Sheikh N, Gomez JE. (2004) Angiotensin-converting enzyme gene polymorphism and lipid profiles in Kuwaiti children with type 1 diabetes. Pediatric Diabetes 5(2):87-94.

  42. Alsaeid K, Kamal H, Haider MZ, El-Enezi H, Malavyia AN. (2004) Systemic lupus erythematosus in Kuwaiti children: organ system involvement and serological findings. Lupus 13:613-617.

  43. Adekile A, Haider MZ, Marouf R, Adekile AD. (2005) HLA-DRB1 alleles among Kuwaiti Hb SS patients with silent brain infarcts and/or avascular necrosis of the femoral head. American Journal of Hematology79:8-10.

  44. Hijazi Z, Onadeko BO, Khadadah M, Haider MZ, Adekile AD, Al-Habashi H. (2005) Pulmonary function studies in Kuwaiti children with sickle cell disease and elevated HbF. International Journal of Clinical Practice 59(2):163-167.

  45. Haider MZ, Adekile AD. (2005) a2-Globin gene polyadenylation (AATAAAàAATAAG) mutation in HbH disease among Kuwaitis. Medical Principles and Practice 14(suppl 1):73-76.

  46. Adekile AD, Haider M, Kutlar F. (2005) Mutations associated with b-thalassemia intermedia in Kuwait. Medical Principles and Practice 14(suppl 1):69-72.

  47. Haider MZ, Habeeb Y, Al-Nakkas E, Al-Anzi H, Zaki M, Al-Tawari A, Al-Bloushi M. (2005) Lack of association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. Journal of Biomedical Science 12:815-818.

  48. Alsaeid K, Haider MZ, Sharma PN, Ayoub EM. (2006) The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. Rheumatology International 26(3):224-228.

  49. Alawadhi AM, Haider MZ, Sharma PN, Hasan EA, Botaiban F, Al-Herz A, Nahar I, Al-Enezi H, Al-Saeid K. (2007) Angiotensin converting enzyme gene polymorphism in Kuwaiti patients with systemic lupus erythematosus. Clinical and Experimental Rheumatology 25(3):437-442.

  50. Adekile A, Al-Kandari M, Haider M, Marouf R, D’Souza M, Sukumaran J. (2007) Hemoglobin F concentration as a function of age in Kuwaiti sickle cell disease patients. Medical Principles & Practice 16:286-290.

  51. Alawadhi AM, Hasan EA, Sharma PN, Haider MZ, Al-Saeid K. (2007) Angiotensin-converting enzyme gene polymorphism in patients with psoriatic arthritis. Rheumatology International 27:1119-1123. 

  52. Uppal SS, Haider MZ, Hayat SJ, Abraham M, Sukumaran J, Dhaunsi G. (2007) Significant association of insertion/deletion polymorphism of the angiotensin converting enzyme gene with rheumatoid arthritis. Journal of Rheumatology 34(12):2395-2399.

  53. Shehab DK, Al-Jarallah KF, Al-Awadhi AM, Al-Herz A, Nahar I, Haider MZ (2008) Association of Angiotensin converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies Journal of Biomedical Science 15:61-67.

  54. Shehab DK, Al-Jarallah KF, Al-Awadhi AM, Al-Herz A, Nahar I, Haider MZ (2008) Prevalence of Angiotensin-converting enzyme (ACE) gene insertion-deletion (I/D) polymorphism in patients with primary knee osteoarthritis. Clinical and Experimental Rheumatology 26:305-310.

  55. Alfadhli S, AlTamimy B, Kharrat N, AlSaeid K, Haider MZ, Rebai A. (2010) Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in systemic lupus erythematosus. International Journal of Immunogenetics 37(1):5-8.

  56. Adekile AD, Haider MZ (2010) Haptoglobin Gene Polymorphisms in Sickle Cell Disease Patients with Different bS-Globin Gene Haplotypes. Medical Principles and Practice 19:447-450. 

  57. Al-Jarallah, KF, Shehab DK, Haider MZ (2011) Prevalence of the Pro12Ala missense mutation in the PPARG2 gene in Kuwaiti patients with primary knee osteoarthritis. Annals of Saudi Medicine 31(1):35-39.

  58. AlFadhli S, AlTamimy B, Alsaeid K, Haider MZ (2011) Endothelial nitric oxide synthase gene haplotypes association with systemic lupus erythematosus. Lupus 20(7):700-708.

  59. Al-Jarallah, KF, Shehab, D, Al-Awadhi A, Nahar I, Haider MZ, Moussa MA. (2012) Is Vitamin-D deficiency  related to knee osteoarthritis and function? Medical Principles & Practice 21:74-78 (DOI: 10.1159/ 000330025).

  60. Al-Jarallah K, Shehab D, Al-Attiyah R, Al-Azemi W, Al-Fadhli A, Haider MZ, Panaccione R, Ghosh S. (2012) Antibodies to mutated citrullinated vimentin and anti-cyclic citrullinated peptide antibodies in inflammatory bowel disease and related arthritis. Inflammatory Bowel Disease 18(9):1655-1662.

  61. Dhaunsi GS, Uppal SS, Haider MZ (2012) Insulin-like growth factor-1 gene polymorphism in rheumatoid arthritis patients. Scandinavian Journal of Rheumatology 2012; 41:421–425; DOI: 10.3109/ 03009742.2012.691177.

 

  1. Adekile AD, Menzel S, Gupta R, Al-Sharida S, Azab AF, Haider M, Akbulut N, Mustafa N, Thein SL (2015) Response to Hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels. American Journal of Hematology 90(7): DOI:10. 1002/ajh.24010.

  2. Al-Eisa AA, Sukumaran VJ, Haider MZ (2016) The prevalence of Paraoxnase1 (PON1) gene polymorphism in Kuwaiti Arab children with idiopathic nephrotic syndrome. Nephron: Experimental Nephrology & Genetics 132:137-143 (DOI: 10.1159/000442998).

  3. Rasoul MA, Al-Mahdi M, Al-Kandari H, Dhaunsi GS, Haider MZ (2016) Low serum vitamin- D status is associated with high prevalence and early onset of type-1 diabetes mellitus in Kuwaiti children. BMC Pediatrics 16:95; DOI: 10.1186/s12887-016-0629-3.

  4. Al-Eisa, AA, Haider MZ (2016) Vitamin D receptor gene TaqI and ApaI polymorphisms and steroid responsiveness in childhood idiopathic nephrotic syndrome. International Journal of Nephrology and Renovascular Disease 9:187-192.

  5. Beyens A, Albuisson J, Boel A, Al-Essa M, Bonnet D, Bostan O, Boute O, Busa T, Canham N, Cil E, Coucke P, Cousin MA, Dasouki M, De Backer J, De Paepe A, De Shepper S, De Silva D, Devriendt K, Dewandele I, Deyle DR, Dietz H, Dupuis-Girod S, Fontenot EE, Fischer-Zirnsak B, Gezdirici A, Ghoumid J, Giuliano F, Diez NB, Haider MZ, Hardin JS, Jeunemaitre X, Klee EW, Kornak U, Landecho MF, Legrand A, Loeys B, Lyonnet S, Michael H, Moceri P, Mohammed S, Muino-Mosquera L, Nampoothiri S, Pilcher K, Prescott K, Rajeb A, Ramos-Arroyo M, Rossi M, Salih M, Seidahmed MZ, Schaefer E, Steichen-Gersdorf E, Temel S, Uysal F, Vanhomwegen M, Van Laer L, Van Maldergem L, Warner D, Willaert A, Collins T, Taylor A, Davis EC, Zarate Y, Callewaert B. Arterial tortuosity syndrome: 40 new families and literature review. Genetics in Medicine 2018 Jan 11. DOI:10.1038/gim.2017.253.

  6. Al-Awadhi AM, Haider MZ, Sukumaran J, Balakrishnan S. (2018) High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility. BMC Rheumatology 2:7; https://doi.org/10.1186/s41927-018-0015-x. 

  7. 95. Haider MZ, Rasoul MA, Al-Mahdi M, Al-Kandari H, Dhaunsi GS (2018) Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T,HLA DQ/DR genotypes and autoantibodies with type-1 diabetes mellitus in Kuwaiti Arabs. PLOS ONE 13(6): e0198652.https://doi.org/10.1371/ journal.pone.0198652.
  8. Rasoul MA, Haider MZ, Al-Mahdi M, Al-Kandari H, Dhaunsi GS (2019) Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children. BMC Pediatrics 19:71

https://doi.org/10.1186/s12887-019-1448-0.

  1. Al-Awadhi AM, Haider MZ, Sukumaran J, Mohammed AT, Hasan EAH, Bartella YA. (2020) Role of protein tyrosine phosphatase (PTPN22) gene [C1858T] functional variant in genetic susceptibility of psoriatic arthritis in Kuwaiti Arabs. The Open Rheumatology Journal 14:15-21. 

    DOI: 10.2174/1874312902014010015, 2020,14,15-21.

  2. Adekile AD, Sukumaran J, Thomas D, D’Souza T, Haider M (2020) Alpha thalassemia genotypes in Kuwait. BMC Medical Genetics 21:170 https://doi.org/10.1186/s12881-020-01105-y.

  3. Al Rushood M, Al-Eisa AA, Haider MZ. (2020) Interleukin-4 and interleukin-13 gene polymorphisms in children with idiopathic nephrotic syndrome. Frontiers in Pediatrics 8:591349, DOI: 10.3389/ fped.2020.591349.
  4. Al-Awadhi AM, Haider MZ, Sukumaran J, Hasan EAH, Bartella YA. (2021) The protein tyrosine phosphatase non-receptor type N22 (PTPN22) gene functional polymorphism (C1858T) is not associated with rheumatoid arthritis in Kuwaiti patients. The Open Rheumatology Journal DOI:10.2174/1874312902115010045, 2021,15,45-50.
  5. Al-Awadhi AM, Haider MZ, Al-Awadi A, Kalarikkal AK, Sukumaran J, Hasan EAH, Bartella YA. (2022) Analysis of association between interleukin-6 (IL6), interleukin-13 (IL13) and Tumor necrosis factor-alpha (TNF-alpha) gene polymorphisms and genetic susceptibility of rheumatic arthritis in Kuwaiti Arabs. Open Journal of Rheumatology and Autoimmune Diseases 12:99-113.
  6. Haider MZ, Al Rushood M, Alsharhan H, Rasoul MA, Al-Mahdi M, Al-Kandari H. (2023) Association of Interleukin-4, Interleukin-13 gene polymorphisms, HLA-DQ and DR genotypes with genetic susceptibility of Type-1 Diabetes Mellitus in Kuwaiti Children. Frontiers in Pediatrics 11:1118137; DOI: 10.3389/fped.2023.1118137.
  7. Al-Awadhi AM, Haider MZ, Al-Awadi A, Sukumaran J, Kalarikkal AK, Hasan EAH, Bartella YA. (2023) Association of interleukin-6 and Tumor necrosis factor-alpha gene polymorphisms with genetic susceptibility of psoriatic arthritis in Kuwaiti Arab patients. The Open Rheumatology Journal DOI:10.2174/18743129-v17-e2023-2, 2023, 17,e187431292306150.
  8. Al-Ahmad M, Ali A, Haider MZ (2023) Interleukin-4 (C590T) gene polymorphism in association with asthma severity. Journal of Asthma and Allergy 16:1269-1278.
  9. Al-Eisa AA, Al Rushood M, Kashyap S, Haider MZ (2023) Tumor necrosis factor alpha gene polymorphism affects the pattern of idiopathic nephrotic syndrome in Kuwaiti Arab children. Journal of Tropical Pediatrics 70(1): DOI https://doi.org/10.1093/tropej/fmad047.
  10. Al-Ahmad M, Ali A, Maher A, Haider MZ (2024) Association between Interleukin-6 -174G/C Gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation. Allergy, Asthma and Clinical Immunology 20:15: https://doi.org/10.1186/s13223-024-00880-0.
  11. Alsharhan H, Haider M, Qadoura B, Ayed M, Dhaunsi GS Alkandari H (2024) Enzymatic Testing for Mucopolysaccharidosis Type I (MPS I) in Kuwaiti Newborns: A Preliminary Study Towards Newborn Screening. Frontiers in Pediatrics DOI 10.3389/fped.2024.1376053.